Checking Out the Centrosome
نویسندگان
چکیده
منابع مشابه
Checking folding inside and out
In This Issue In This Issue he ER is a site of both synthesis and quality control. Rejected, improperly folded proteins are destroyed by a well-characterized machinery (the ER-associated degradation [ERAD] pathway) in the cytosol and ER membrane that extracts and chews up any unfolded proteins. But the mechanisms for recognizing unfolded proteins as targets for destruction are less well charact...
متن کاملThe centrosome
All cells are polar. This is particularly evident in eukaryotic cells, where an organized cytoskeleton is used to differentiate parts of the cell. Microtubules — an important part of this cytoskeleton — are especially well suited to playing a part in cell polarity because of their own intrinsic polarity. And the centrosome, the unique organelle that organizes microtubules into useful arrays, is...
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As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
متن کاملCentrosome-associated NDR kinase regulates centrosome duplication.
Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of NDR resulted in centrosome overduplicat...
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classify specified organisms taxonomically, determine the origins of proteinencoding genes, and infer how proteins function based on their conserved sequence motifs. Typically, phylogenic analysis involves two steps: constructing a phylogenetic tree or network based on the given biosequences and deriving biological information from the tree or network. Many computational methods have been devel...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2004
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.3.11.1252